Transportation of Drug-(Polystyrene Bead) Conjugate by Actomyosin Motor System

Kaur, Harsimran and Kumar, Suresh and Kukkar, Deepak and Kaur, Inderpreet and Singh, Kashmir and Bharadwaj, L.M. (2010) Transportation of Drug-(Polystyrene Bead) Conjugate by Actomyosin Motor System. Journal of Biomedical Nanotechnology, 6 (3). pp. 279-286. ISSN ISSN: 1550-7033 (Print): EISSN: 1550-7041 (Online)

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The Nanorobotics and cargo transportation application of molecular motors is of recent intent. The present study explores the transportation of Mesalamine/5-aminosalicylic acid/5-ASA drug by molecular motors. Mesalamine is an anti-inflammatory drug used to treat Crohn's disease and ulcerative colitis. Conjugate of mesalamine and polystyrene (Dia.: 3 μm) beads was prepared by amide linkage between amine (-NH2 group of drug and carboxyl (-COOH) group of the bead. In Fourier Transform Infrared spectra, peaks were observed at 3428.1 and 1654.0 cm-1 for N-H and C=O stretching bond respectively confirming the amide bond formation between drug and microbeads. Quantification of 5-ASA attached to polystyrene bead was done by UV-vis spectroscopy and it was ascertained that 93% of 5-ASA was loaded on polystyrene beads. Conjugate of drug-polystyrene beads were then covalently attached to actin filaments. Velocity of actin filaments attached to drug loaded beads in in-vitro motility assay reduced to 0.89 m/s as compared to free actin velocity (4.64 m/s). This further ascertains the microcomposites formation. The present study provides an insight into the actin-myosin based molecular motor systems for an efficient tool for drug transportation.

Item Type: Article
Subjects: CSIO > Nano Science and Nano Technology
Depositing User: Ms T Kaur
Date Deposited: 29 Jan 2012 20:37
Last Modified: 10 Apr 2012 15:13

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