Bioconjugation of MOF-5 for molecular sensing

Kumar, Pawan and Deep, Akash and Paul, A.K. and Bharadwaj, L.M. (2014) Bioconjugation of MOF-5 for molecular sensing. Journal of Porous Materials, 21 (1). pp. 99-104. ISSN 1380-2224 Print , 1573-4854 Online

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Zn-BDC (BDC = 1,4-benzenedicarboxylate acid) or more commonly known as metal organic framework (MOF-5) was synthesized via chemical stirring method and bioconjugated with anti-bovine serum albumin (anti-BSA) through pendent group. The pendent group of organic linker on surface of MOF-5 has been activated via EDC (1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide) based simple organic reaction and then bioconjugation of anti-BSA was achieved. Bioconjugation of anti-BSA on to MOF-5 has been used to study the interaction with BSA based on their fluorescence properties. Fluorescent microscopy revealed successful interaction of anti-BSA with BSA onto MOF-5 surface. In addition, BSA conjugated MOF-5 showed no loss of enantioselectivity and structure stability. Photoluminescence quenching of the developed probe was demonstrated to observe the presence of BSA.

Item Type: Article
Subjects: CSIO > Nano Science and Nano Technology
Divisions: Nano Science and Nano Technology
Depositing User: Ms. J Shrivastav
Date Deposited: 21 Mar 2014 11:26
Last Modified: 21 Mar 2014 11:26

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