Graphene-gated biochip for the detection of cardiac marker Troponin I

Tuteja, S.K. and ., Priyanka and Bhalla, Vijayender and Deep, Akash and Paul, A.K. and Suri, C.R. (2014) Graphene-gated biochip for the detection of cardiac marker Troponin I. Analytica Chimica Acta, 809. pp. 148-154. ISSN 0003-2670

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We report lithium ion intercalation mediated efficient exfoliation of graphite to form monolithic graphene sheets which have subsequently been investigated for the development of highly sensitive label-free electrochemical detection platform for cardiac biomarker, Troponin I (cTnI). The spectroscopic and morphological analysis demonstrated the formation of defect free graphene sheets which were successfully employed to fabricate an inter-digited microdevice in a drain-source configuration on a silicon biochip. The graphene gated biochip functionalized with anti-cTnI antibodies used in label free detection of cTnI which exhibited an excellent sensitivity in the picogram range (~1 pg mL(-1)) for cTnI without the use of any enzymatic amplification that promises its potential applicability for bio-molecular detection in clinical diagnosis.

Item Type: Article
Uncontrolled Keywords: Biochip; Graphene sheets; Lithium ion intercalation; Troponin I
Subjects: CSIO > Medical Instrumentation
CSIO > Nano Science and Nano Technology
Divisions: Nano Science and Nano Technology
Depositing User: Ms. Jyotsana
Date Deposited: 09 Aug 2018 12:06
Last Modified: 09 Aug 2018 12:06

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