Biofunctionalized rebar graphene (f-RG) for label-free detection of cardiac marker troponin I

Tuteja, S.K. and Sabherwal, Priyanka and Deep, Akash and Rastogi, Richa and Paul, A.K. and Suri, C.R. (2014) Biofunctionalized rebar graphene (f-RG) for label-free detection of cardiac marker troponin I. ACS Applied Materials and Interfaces, 6. pp. 14767-14771. ISSN 1944-8244

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Official URL: http://pubs.acs.org/doi/abs/10.1021/am503524e?jour...

Abstract

One-step microwave-assisted unscrolling of carbon nanotubes to form functionalized rebar graphene (f-RG) is reported. The well-characterized f-RG on an interdigitated electrode biochip in a FET configuration showed enhanced electronic properties, as demonstrated with I-V characteristics. The developed device was biofunctionalized with specific anti-cTnI antibodies exhibiting a shift of threshold voltage from -2.15 V to -0.5 V and decrease in electron mobility from 3.609 × 10(4) to 8.877 × 10(3) cm(2) V(-1) s(-1). The new sensing strategy holds great promise for its applicability in diagnostics exhibiting high sensitivity (∼ 1 pg/mL) and specificity toward cardiac marker (cTnI).

Item Type: Article
Uncontrolled Keywords: biochip; carbon nanotubes; cardiac marker; clinical diagnostics; functionalized rebar graphene; troponin I
Subjects: CSIO > Materials Science
CSIO > Nano Science and Nano Technology
Divisions: Nano Science and Nano Technology
Depositing User: Ms. Jyotsana
Date Deposited: 20 Jul 2015 10:48
Last Modified: 20 Jul 2015 10:48
URI: http://csioir.csio.res.in/id/eprint/490

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